At the University of Pittsburgh, the Wei lab is looking for a self-motivated postdoc to study the expression regulation and functions of epithelial polarity genes in zebrafish development. Specifically, we are interested in identifying what transcription factors, cis-regulatory elements (CREs), and chromosome architectural and other epigenetic properties regulate cell-type-specific expression of epithelial polarity genes during neural development. In addition, we are also interested in understanding how polarity genes regulate cell-cell and cell-matrix adhesions for proper cellular patterning during tissue morphogenesis. Our research uses a variety of technologies, such as recombinant DNA technologies, bioinformatic prediction of CREs, RNA and DNA FISH, immunohistochemistry, confocal microscopy, transgenic animals, etc. For examples of our research interests, please refer to the following publications:
- Guo, J. Zou, Y. Wen, W. Fang, D. Stolz, M. Sun, X. Wei (2018) Apical cell-cell adhesions reconcile symmetry and asymmetry in zebrafish neurulation. iScience 3:63-85.
- Fang, C. Guo, X. Wei (2017) Rainbow Enhancers Regulate Restrictive Transcription in Teleost Green, Red, and Blue Cones. Journal of Neuroscience. 37(11):2834-2848.
- Zou, X. Wang, and X. Wei (2012) Crb apical polarity proteins maintain zebrafish retinal cone mosaics via intercellular binding of their extracellular domains. Developmental Cell. 22, 1261–1274.
- Yang, J. Zou, D. Hyde, L. Davidson, and X. Wei (2009) Stepwise maturation of apicobasal polarity of the neuroepithelium is essential for vertebrate neurulation. Journal of Neuroscience. 29:11426-11440.
- J. Zou, K. Lathrop, M. Sun, X. Wei (2008) Intact RPE maintained by Nok is essential for retinal epithelial polarity and cellular patterning in zebrafish. Journal of Neuroscience. 28(50):13684 –13695.
Location/Region: Pittsburgh, PA (15201)